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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of designing a study that include the recruitment process and consent, adhering and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from different geographic areas. This type of heterogeneity which is essential for pragmatic trials to be valid and reduce bias in results, is also necessary. However too much heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They can be used to determine the causality of an intervention with its outcomes. However, they should not be used as a substitute for explanation trials.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as monitoring.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), 프라그마틱 슬롯 하는법 슬롯무료 (visit the up coming internet page) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.